The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice. [electronic resource]
Producer: 20020507Description: 89-95 p. digitalISSN:- 0378-6501
- Animals
- Carbamates -- chemistry
- Cells, Cultured
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- chemistry
- Enzyme-Linked Immunosorbent Assay
- Graft Rejection -- physiopathology
- Graft Survival -- drug effects
- Graft vs Host Disease -- drug therapy
- IMP Dehydrogenase -- antagonists & inhibitors
- Immunosuppressive Agents -- therapeutic use
- Interferon-gamma -- blood
- Mice
- Mice, Inbred Strains
- Models, Animal
- Phenylurea Compounds -- chemistry
- Skin -- immunology
- Skin Transplantation -- immunology
- Spleen -- immunology
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Publication Type: Journal Article
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