The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice.

Decker, C J

The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice. [electronic resource] - Drugs under experimental and clinical research 2001 - 89-95 p. digital

Publication Type: Journal Article

0378-6501


Animals
Carbamates--chemistry
Cells, Cultured
Dose-Response Relationship, Drug
Enzyme Inhibitors--chemistry
Enzyme-Linked Immunosorbent Assay
Graft Rejection--physiopathology
Graft Survival--drug effects
Graft vs Host Disease--drug therapy
IMP Dehydrogenase--antagonists & inhibitors
Immunosuppressive Agents--therapeutic use
Interferon-gamma--blood
Mice
Mice, Inbred Strains
Models, Animal
Phenylurea Compounds--chemistry
Skin--immunology
Skin Transplantation--immunology
Spleen--immunology