In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats. [electronic resource]
Producer: 20010614Description: 1129-36 p. digitalISSN:- 0022-3565
- Animals
- Chemical and Drug Induced Liver Injury
- Dose-Response Relationship, Drug
- Drug Delivery Systems -- methods
- Drug Stability
- Endosomes
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Injections, Intravenous
- Lipopolysaccharides -- pharmacology
- Liposomes
- Liver -- drug effects
- Liver Diseases -- metabolism
- Male
- Oligonucleotides, Antisense -- administration & dosage
- Organothiophosphorus Compounds -- administration & dosage
- Phosphorothioate Oligonucleotides
- RNA, Messenger -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Spleen -- metabolism
- Tissue Distribution
- Treatment Outcome
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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