In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats.

Ponnappa, B C

In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 2001 - 1129-36 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-3565


Animals
Chemical and Drug Induced Liver Injury
Dose-Response Relationship, Drug
Drug Delivery Systems--methods
Drug Stability
Endosomes
Hydrogen-Ion Concentration
In Vitro Techniques
Injections, Intravenous
Lipopolysaccharides--pharmacology
Liposomes
Liver--drug effects
Liver Diseases--metabolism
Male
Oligonucleotides, Antisense--administration & dosage
Organothiophosphorus Compounds--administration & dosage
Phosphorothioate Oligonucleotides
RNA, Messenger--antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Spleen--metabolism
Tissue Distribution
Treatment Outcome
Tumor Necrosis Factor-alpha--antagonists & inhibitors