Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency. [electronic resource]
Producer: 20010719Description: 1149-53 p. digitalISSN:- 1078-0432
- Adult
- Antimetabolites, Antineoplastic -- metabolism
- Dihydrouracil Dehydrogenase (NADP)
- Exons -- genetics
- Fatal Outcome
- Female
- Fibroblasts -- enzymology
- Fluorouracil -- metabolism
- Gene Frequency
- Humans
- Leukocytes, Mononuclear -- enzymology
- Mutation
- Oxidoreductases -- deficiency
- Polymorphism, Restriction Fragment Length
- Thymine -- blood
- Uracil -- blood
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Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
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