Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
van Kuilenburg, A B
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research May 2001 - 1149-53 p. digital
Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
1078-0432
Adult
Antimetabolites, Antineoplastic--metabolism
Dihydrouracil Dehydrogenase (NADP)
Exons--genetics
Fatal Outcome
Female
Fibroblasts--enzymology
Fluorouracil--metabolism
Gene Frequency
Humans
Leukocytes, Mononuclear--enzymology
Mutation
Oxidoreductases--deficiency
Polymorphism, Restriction Fragment Length
Thymine--blood
Uracil--blood
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research May 2001 - 1149-53 p. digital
Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
1078-0432
Adult
Antimetabolites, Antineoplastic--metabolism
Dihydrouracil Dehydrogenase (NADP)
Exons--genetics
Fatal Outcome
Female
Fibroblasts--enzymology
Fluorouracil--metabolism
Gene Frequency
Humans
Leukocytes, Mononuclear--enzymology
Mutation
Oxidoreductases--deficiency
Polymorphism, Restriction Fragment Length
Thymine--blood
Uracil--blood