6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity. [electronic resource]
Producer: 20011101Description: 637-45 p. digitalISSN:- 0968-0896
- Animals
- Cathepsin G
- Cathepsins -- antagonists & inhibitors
- Cattle
- Chymotrypsin -- antagonists & inhibitors
- Drug Stability
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Indoles -- chemical synthesis
- Kinetics
- Leukocyte Elastase -- antagonists & inhibitors
- Models, Molecular
- Pancreatic Elastase -- antagonists & inhibitors
- Serine Endopeptidases
- Stereoisomerism
- Structure-Activity Relationship
- Substrate Specificity
- Swine
- Thermodynamics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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