6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity.
Vagnoni, L M
6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity. [electronic resource] - Bioorganic & medicinal chemistry Mar 2001 - 637-45 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0968-0896
10.1016/s0968-0896(00)00281-9 doi
Animals
Cathepsin G
Cathepsins--antagonists & inhibitors
Cattle
Chymotrypsin--antagonists & inhibitors
Drug Stability
Enzyme Inhibitors--chemical synthesis
Humans
Indoles--chemical synthesis
Kinetics
Leukocyte Elastase--antagonists & inhibitors
Models, Molecular
Pancreatic Elastase--antagonists & inhibitors
Serine Endopeptidases
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity
Swine
Thermodynamics
6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity. [electronic resource] - Bioorganic & medicinal chemistry Mar 2001 - 637-45 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0968-0896
10.1016/s0968-0896(00)00281-9 doi
Animals
Cathepsin G
Cathepsins--antagonists & inhibitors
Cattle
Chymotrypsin--antagonists & inhibitors
Drug Stability
Enzyme Inhibitors--chemical synthesis
Humans
Indoles--chemical synthesis
Kinetics
Leukocyte Elastase--antagonists & inhibitors
Models, Molecular
Pancreatic Elastase--antagonists & inhibitors
Serine Endopeptidases
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity
Swine
Thermodynamics