Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. [electronic resource]
Producer: 20010208Description: 72-80 p. digitalISSN:- 0022-1767
- Adenylyl Cyclase Inhibitors
- Adenylyl Cyclases -- metabolism
- Adjuvants, Immunologic -- antagonists & inhibitors
- Adult
- Cyclic AMP -- metabolism
- Cyclic AMP-Dependent Protein Kinase Type II
- Cyclic AMP-Dependent Protein Kinases -- antagonists & inhibitors
- Enzyme Activation -- drug effects
- Female
- Gangliosides -- antagonists & inhibitors
- Humans
- Immunosuppressive Agents -- antagonists & inhibitors
- Interferon-gamma -- biosynthesis
- Interleukin-2 -- biosynthesis
- Interleukin-4 -- antagonists & inhibitors
- Interleukin-5 -- antagonists & inhibitors
- Jurkat Cells
- Lymphocyte Activation -- drug effects
- Male
- Middle Aged
- Phosphoric Diester Hydrolases -- metabolism
- Phytohemagglutinins -- antagonists & inhibitors
- Promoter Regions, Genetic -- drug effects
- RNA, Messenger -- antagonists & inhibitors
- T-Lymphocytes -- drug effects
- Th1 Cells -- drug effects
- Th2 Cells -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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