Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells.

Kanda, N

Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Jan 2001 - 72-80 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-1767

10.4049/jimmunol.166.1.72 doi


Adenylyl Cyclase Inhibitors
Adenylyl Cyclases--metabolism
Adjuvants, Immunologic--antagonists & inhibitors
Adult
Cyclic AMP--metabolism
Cyclic AMP-Dependent Protein Kinase Type II
Cyclic AMP-Dependent Protein Kinases--antagonists & inhibitors
Enzyme Activation--drug effects
Female
Gangliosides--antagonists & inhibitors
Humans
Immunosuppressive Agents--antagonists & inhibitors
Interferon-gamma--biosynthesis
Interleukin-2--biosynthesis
Interleukin-4--antagonists & inhibitors
Interleukin-5--antagonists & inhibitors
Jurkat Cells
Lymphocyte Activation--drug effects
Male
Middle Aged
Phosphoric Diester Hydrolases--metabolism
Phytohemagglutinins--antagonists & inhibitors
Promoter Regions, Genetic--drug effects
RNA, Messenger--antagonists & inhibitors
T-Lymphocytes--drug effects
Th1 Cells--drug effects
Th2 Cells--drug effects