Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling. [electronic resource]
Producer: 20001207Description: 475-84 p. digitalISSN:- 1074-7613
- Alanine -- metabolism
- Amino Acid Substitution -- immunology
- Cells, Cultured
- Crystallography, X-Ray
- Cytotoxicity Tests, Immunologic
- Gene Products, tax -- chemistry
- Glycine -- metabolism
- HLA-A2 Antigen -- metabolism
- Humans
- Ligands
- Peptides -- chemistry
- Proline -- metabolism
- Protein Binding -- immunology
- Protein Folding
- Receptors, Antigen, T-Cell, alpha-beta -- agonists
- Sarcosine -- metabolism
- Signal Transduction -- immunology
- T-Lymphocytes, Cytotoxic -- immunology
- Thermodynamics
- Ultracentrifugation -- methods
- Water
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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