The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. [electronic resource]
Producer: 20001116Description: 4350-5 p. digitalISSN:- 1362-4962
- Acidosis, Lactic -- genetics
- Adult
- Aged
- Aged, 80 and over
- Aging -- genetics
- Brain -- growth & development
- DNA Mutational Analysis -- methods
- DNA, Mitochondrial -- genetics
- Epilepsies, Myoclonic -- genetics
- Female
- Humans
- Male
- Middle Aged
- Muscle Development
- Muscle, Skeletal -- growth & development
- Peptide Nucleic Acids -- genetics
- Plasmids -- genetics
- Point Mutation -- genetics
- Polymerase Chain Reaction -- methods
- Promoter Regions, Genetic -- genetics
- RNA, Transfer, Leu -- genetics
- RNA, Transfer, Lys -- genetics
- Sensitivity and Specificity
- Stroke -- genetics
- Templates, Genetic
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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