The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method.

Murdock, D G

The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. [electronic resource] - Nucleic acids research Nov 2000 - 4350-5 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1362-4962

10.1093/nar/28.21.4350 doi


Acidosis, Lactic--genetics
Adult
Aged
Aged, 80 and over
Aging--genetics
Brain--growth & development
DNA Mutational Analysis--methods
DNA, Mitochondrial--genetics
Epilepsies, Myoclonic--genetics
Female
Humans
Male
Middle Aged
Muscle Development
Muscle, Skeletal--growth & development
Peptide Nucleic Acids--genetics
Plasmids--genetics
Point Mutation--genetics
Polymerase Chain Reaction--methods
Promoter Regions, Genetic--genetics
RNA, Transfer, Leu--genetics
RNA, Transfer, Lys--genetics
Sensitivity and Specificity
Stroke--genetics
Templates, Genetic