CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1. [electronic resource]
Producer: 20001219Description: 8409-19 p. digitalISSN:- 0270-7306
- Animals
- CD28 Antigens -- metabolism
- CD3 Complex -- metabolism
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Flavonoids -- pharmacology
- Humans
- Jurkat Cells -- drug effects
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck) -- genetics
- MAP Kinase Signaling System
- Mice
- Mice, Inbred C57BL
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Receptors, Antigen, T-Cell -- drug effects
- T-Lymphocytes -- metabolism
- rap1 GTP-Binding Proteins -- metabolism
- ras Proteins -- genetics
- src Homology Domains
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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