CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

Carey, K D

CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1. [electronic resource] - Molecular and cellular biology Nov 2000 - 8409-19 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0270-7306

10.1128/MCB.20.22.8409-8419.2000 doi


Animals
CD28 Antigens--metabolism
CD3 Complex--metabolism
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Flavonoids--pharmacology
Humans
Jurkat Cells--drug effects
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)--genetics
MAP Kinase Signaling System
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors
Receptors, Antigen, T-Cell--drug effects
T-Lymphocytes--metabolism
rap1 GTP-Binding Proteins--metabolism
ras Proteins--genetics
src Homology Domains