Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. [electronic resource]
Producer: 20001115Description: 1065-70 p. digitalISSN:- 1087-0156
- Angiogenesis Inhibitors -- chemistry
- Animals
- Antineoplastic Agents -- chemistry
- Cell Division -- drug effects
- Cell Line
- DNA -- biosynthesis
- Drug Design
- Endothelial Growth Factors -- antagonists & inhibitors
- Enzyme Activation -- drug effects
- Glioblastoma -- blood supply
- Humans
- Inhibitory Concentration 50
- Lymphokines -- antagonists & inhibitors
- Mice
- Mice, Nude
- Mitogen-Activated Protein Kinases -- metabolism
- Neoplasm Transplantation
- Neovascularization, Pathologic -- drug therapy
- Peptides, Cyclic -- chemistry
- Phosphorylation -- drug effects
- Platelet-Derived Growth Factor -- antagonists & inhibitors
- Receptor Protein-Tyrosine Kinases -- metabolism
- Receptors, Growth Factor -- metabolism
- Receptors, Platelet-Derived Growth Factor -- antagonists & inhibitors
- Receptors, Vascular Endothelial Growth Factor
- Substrate Specificity
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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