Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.

Blaskovich, M A

Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. [electronic resource] - Nature biotechnology Oct 2000 - 1065-70 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

1087-0156

10.1038/80257 doi


Angiogenesis Inhibitors--chemistry
Animals
Antineoplastic Agents--chemistry
Cell Division--drug effects
Cell Line
DNA--biosynthesis
Drug Design
Endothelial Growth Factors--antagonists & inhibitors
Enzyme Activation--drug effects
Glioblastoma--blood supply
Humans
Inhibitory Concentration 50
Lymphokines--antagonists & inhibitors
Mice
Mice, Nude
Mitogen-Activated Protein Kinases--metabolism
Neoplasm Transplantation
Neovascularization, Pathologic--drug therapy
Peptides, Cyclic--chemistry
Phosphorylation--drug effects
Platelet-Derived Growth Factor--antagonists & inhibitors
Receptor Protein-Tyrosine Kinases--metabolism
Receptors, Growth Factor--metabolism
Receptors, Platelet-Derived Growth Factor--antagonists & inhibitors
Receptors, Vascular Endothelial Growth Factor
Substrate Specificity
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors