Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1. [electronic resource]
Producer: 20000817Description: 71-84 p. digitalISSN:- 0077-8923
- CDC2-CDC28 Kinases
- Carrier Proteins -- metabolism
- Cell Cycle
- Cell Cycle Proteins
- Cells, Cultured
- Cellular Senescence -- physiology
- Cyclin E -- metabolism
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases -- metabolism
- DNA-Binding Proteins
- Down-Regulation
- E2F Transcription Factors
- E2F1 Transcription Factor
- Enzyme Activation
- Humans
- Melanins -- metabolism
- Melanocytes -- cytology
- Phosphorylation
- Pigments, Biological -- physiology
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins
- Retinoblastoma Protein -- metabolism
- Retinoblastoma-Binding Protein 1
- Thymidylate Synthase -- metabolism
- Transcription Factor DP1
- Transcription Factors -- metabolism
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Publication Type: Journal Article
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