Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1.

Bandyopadhyay, D

Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1. [electronic resource] - Annals of the New York Academy of Sciences Jun 2000 - 71-84 p. digital

Publication Type: Journal Article

0077-8923

10.1111/j.1749-6632.2000.tb06637.x doi


CDC2-CDC28 Kinases
Carrier Proteins--metabolism
Cell Cycle
Cell Cycle Proteins
Cells, Cultured
Cellular Senescence--physiology
Cyclin E--metabolism
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases--metabolism
DNA-Binding Proteins
Down-Regulation
E2F Transcription Factors
E2F1 Transcription Factor
Enzyme Activation
Humans
Melanins--metabolism
Melanocytes--cytology
Phosphorylation
Pigments, Biological--physiology
Protein Serine-Threonine Kinases--metabolism
Proto-Oncogene Proteins
Retinoblastoma Protein--metabolism
Retinoblastoma-Binding Protein 1
Thymidylate Synthase--metabolism
Transcription Factor DP1
Transcription Factors--metabolism