Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. [electronic resource]
Producer: 20000816Description: 1797-809 p. digitalISSN:- 0890-9369
- 3T3 Cells
- Age Factors
- Animals
- Cell Division
- Cells, Cultured
- DNA, Complementary -- metabolism
- Female
- Fibroblasts -- metabolism
- Gene Library
- Genotype
- Heterozygote
- Humans
- Interleukin-2 -- pharmacology
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Models, Genetic
- Mutagenesis, Site-Directed
- Neoplasms, Experimental -- chemically induced
- Phenotype
- Proteins -- metabolism
- T-Lymphocytes -- cytology
- Time Factors
- Tissue Distribution
- Transcription Factors -- biosynthesis
- Transformation, Genetic
- Tumor Suppressor Protein p14ARF
- Tumor Suppressor Protein p53 -- metabolism
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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