Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.

Inoue, K

Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. [electronic resource] - Genes & development Jul 2000 - 1797-809 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0890-9369


3T3 Cells
Age Factors
Animals
Cell Division
Cells, Cultured
DNA, Complementary--metabolism
Female
Fibroblasts--metabolism
Gene Library
Genotype
Heterozygote
Humans
Interleukin-2--pharmacology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Genetic
Mutagenesis, Site-Directed
Neoplasms, Experimental--chemically induced
Phenotype
Proteins--metabolism
T-Lymphocytes--cytology
Time Factors
Tissue Distribution
Transcription Factors--biosynthesis
Transformation, Genetic
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53--metabolism
ras Proteins--metabolism