DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. [electronic resource]
Producer: 20000912Description: 1671-9 p. digitalISSN:- 0964-6906
- Binding Sites
- Cell Line
- Chromatin -- genetics
- DNA Topoisomerases, Type II -- metabolism
- DNA, Neoplasm -- chemistry
- DNA-Binding Proteins -- genetics
- Deoxyribonuclease I -- metabolism
- Histone-Lysine N-Methyltransferase
- Humans
- Introns
- Jurkat Cells
- K562 Cells
- Leukemia -- genetics
- Molecular Sequence Data
- Myeloid-Lymphoid Leukemia Protein
- Nuclear Proteins -- genetics
- Oncogene Proteins, Fusion -- genetics
- Proto-Oncogenes
- Recombination, Genetic
- Sequence Analysis, DNA
- Transcription Factors
- Translocation, Genetic
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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