DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.
Strissel, P L
DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. [electronic resource] - Human molecular genetics Jul 2000 - 1671-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0964-6906
10.1093/hmg/9.11.1671 doi
Binding Sites
Cell Line
Chromatin--genetics
DNA Topoisomerases, Type II--metabolism
DNA, Neoplasm--chemistry
DNA-Binding Proteins--genetics
Deoxyribonuclease I--metabolism
Histone-Lysine N-Methyltransferase
Humans
Introns
Jurkat Cells
K562 Cells
Leukemia--genetics
Molecular Sequence Data
Myeloid-Lymphoid Leukemia Protein
Nuclear Proteins--genetics
Oncogene Proteins, Fusion--genetics
Proto-Oncogenes
Recombination, Genetic
Sequence Analysis, DNA
Transcription Factors
Translocation, Genetic
Tumor Cells, Cultured
DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. [electronic resource] - Human molecular genetics Jul 2000 - 1671-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0964-6906
10.1093/hmg/9.11.1671 doi
Binding Sites
Cell Line
Chromatin--genetics
DNA Topoisomerases, Type II--metabolism
DNA, Neoplasm--chemistry
DNA-Binding Proteins--genetics
Deoxyribonuclease I--metabolism
Histone-Lysine N-Methyltransferase
Humans
Introns
Jurkat Cells
K562 Cells
Leukemia--genetics
Molecular Sequence Data
Myeloid-Lymphoid Leukemia Protein
Nuclear Proteins--genetics
Oncogene Proteins, Fusion--genetics
Proto-Oncogenes
Recombination, Genetic
Sequence Analysis, DNA
Transcription Factors
Translocation, Genetic
Tumor Cells, Cultured