Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions. [electronic resource]
Producer: 20000721Description: 7107-16 p. digitalISSN:- 0006-2960
- Antioxidants -- pharmacology
- Berberine Alkaloids -- chemistry
- DNA -- chemistry
- DNA Topoisomerases, Type I -- chemistry
- DNA Topoisomerases, Type II -- chemistry
- Humans
- Intercalating Agents -- chemistry
- Models, Molecular
- Molecular Structure
- Nucleic Acid Conformation -- drug effects
- Nucleic Acid Denaturation -- drug effects
- Protein Binding
- Temperature
- Thermodynamics
- Viscosity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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