Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.

Li, T K

Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions. [electronic resource] - Biochemistry Jun 2000 - 7107-16 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-2960

10.1021/bi000171g doi


Antioxidants--pharmacology
Berberine Alkaloids--chemistry
DNA--chemistry
DNA Topoisomerases, Type I--chemistry
DNA Topoisomerases, Type II--chemistry
Humans
Intercalating Agents--chemistry
Models, Molecular
Molecular Structure
Nucleic Acid Conformation--drug effects
Nucleic Acid Denaturation--drug effects
Protein Binding
Temperature
Thermodynamics
Viscosity