The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. [electronic resource]
Producer: 19991208Description: 752-9 p. digitalISSN:- 0022-202X
- Adult
- Aged
- CD4-CD8 Ratio
- Cell Differentiation -- drug effects
- Cytokines -- biosynthesis
- Epidermal Cells
- Female
- Humans
- Interferon-gamma -- biosynthesis
- Interleukin-2 -- biosynthesis
- Ionomycin -- pharmacology
- Lymphocyte Activation -- drug effects
- Male
- Middle Aged
- Psoriasis -- blood
- T-Lymphocytes -- drug effects
- T-Lymphocytes, Cytotoxic -- metabolism
- Tetradecanoylphorbol Acetate -- pharmacology
- Th1 Cells -- cytology
- Tumor Necrosis Factor-alpha -- biosynthesis
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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