The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients.

Austin, L M

The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. [electronic resource] - The Journal of investigative dermatology Nov 1999 - 752-9 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-202X

10.1046/j.1523-1747.1999.00749.x doi


Adult
Aged
CD4-CD8 Ratio
Cell Differentiation--drug effects
Cytokines--biosynthesis
Epidermal Cells
Female
Humans
Interferon-gamma--biosynthesis
Interleukin-2--biosynthesis
Ionomycin--pharmacology
Lymphocyte Activation--drug effects
Male
Middle Aged
Psoriasis--blood
T-Lymphocytes--drug effects
T-Lymphocytes, Cytotoxic--metabolism
Tetradecanoylphorbol Acetate--pharmacology
Th1 Cells--cytology
Tumor Necrosis Factor-alpha--biosynthesis