Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity. [electronic resource]
Producer: 19991217Description: 1105-15 p. digitalISSN:- 0026-895X
- Alanine -- genetics
- Amino Acid Substitution
- Camptothecin -- pharmacology
- Catalysis
- DNA -- drug effects
- DNA Topoisomerases, Type I -- chemistry
- Drug Resistance
- Enzyme Inhibitors -- pharmacology
- Enzyme Stability
- Glycine -- genetics
- Humans
- Models, Molecular
- Mutation
- Protein Conformation
- Protein Structure, Tertiary
- Saccharomyces cerevisiae -- genetics
- Threonine -- genetics
- Topoisomerase I Inhibitors
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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