Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

Fiorani, P

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity. [electronic resource] - Molecular pharmacology Dec 1999 - 1105-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0026-895X

10.1124/mol.56.6.1105 doi


Alanine--genetics
Amino Acid Substitution
Camptothecin--pharmacology
Catalysis
DNA--drug effects
DNA Topoisomerases, Type I--chemistry
Drug Resistance
Enzyme Inhibitors--pharmacology
Enzyme Stability
Glycine--genetics
Humans
Models, Molecular
Mutation
Protein Conformation
Protein Structure, Tertiary
Saccharomyces cerevisiae--genetics
Threonine--genetics
Topoisomerase I Inhibitors
Transfection