Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS. [electronic resource]
Producer: 19991202Description: 833-50 p. digitalISSN:- 0278-5846
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Amyotrophic Lateral Sclerosis -- enzymology
- Animals
- Blotting, Western
- COS Cells
- Cyclin-Dependent Kinase 5
- Cyclin-Dependent Kinases -- metabolism
- DNA Primers
- Epitope Mapping
- Epitopes -- biosynthesis
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Sequence Data
- Motor Neurons -- enzymology
- Neurofilament Proteins -- immunology
- Peptide Fragments -- chemical synthesis
- Phosphorylation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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