Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS.
Bajaj, N P
Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS. [electronic resource] - Progress in neuro-psychopharmacology & biological psychiatry Jul 1999 - 833-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0278-5846
10.1016/s0278-5846(99)00044-5 doi
Aged
Aged, 80 and over
Amino Acid Sequence
Amyotrophic Lateral Sclerosis--enzymology
Animals
Blotting, Western
COS Cells
Cyclin-Dependent Kinase 5
Cyclin-Dependent Kinases--metabolism
DNA Primers
Epitope Mapping
Epitopes--biosynthesis
Female
Humans
Immunohistochemistry
Male
Middle Aged
Molecular Sequence Data
Motor Neurons--enzymology
Neurofilament Proteins--immunology
Peptide Fragments--chemical synthesis
Phosphorylation
Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS. [electronic resource] - Progress in neuro-psychopharmacology & biological psychiatry Jul 1999 - 833-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0278-5846
10.1016/s0278-5846(99)00044-5 doi
Aged
Aged, 80 and over
Amino Acid Sequence
Amyotrophic Lateral Sclerosis--enzymology
Animals
Blotting, Western
COS Cells
Cyclin-Dependent Kinase 5
Cyclin-Dependent Kinases--metabolism
DNA Primers
Epitope Mapping
Epitopes--biosynthesis
Female
Humans
Immunohistochemistry
Male
Middle Aged
Molecular Sequence Data
Motor Neurons--enzymology
Neurofilament Proteins--immunology
Peptide Fragments--chemical synthesis
Phosphorylation