Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis. [electronic resource]
Producer: 19991028Description: 1853-66 p. digitalISSN:- 1043-0342
- Amyotrophic Lateral Sclerosis -- therapy
- Animals
- Cell Transplantation
- Disease Models, Animal
- Disease Progression
- Genetic Therapy
- Genetic Vectors
- Glial Cell Line-Derived Neurotrophic Factor
- Humans
- Mice
- Motor Neurons -- physiology
- Muscle, Skeletal -- cytology
- Nerve Growth Factors
- Nerve Tissue Proteins -- genetics
- Retroviridae -- genetics
- Transduction, Genetic
- beta-Galactosidase -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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