Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis.
Mohajeri, M H
Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis. [electronic resource] - Human gene therapy Jul 1999 - 1853-66 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1043-0342
10.1089/10430349950017536 doi
Amyotrophic Lateral Sclerosis--therapy
Animals
Cell Transplantation
Disease Models, Animal
Disease Progression
Genetic Therapy
Genetic Vectors
Glial Cell Line-Derived Neurotrophic Factor
Humans
Mice
Motor Neurons--physiology
Muscle, Skeletal--cytology
Nerve Growth Factors
Nerve Tissue Proteins--genetics
Retroviridae--genetics
Transduction, Genetic
beta-Galactosidase--genetics
Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis. [electronic resource] - Human gene therapy Jul 1999 - 1853-66 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1043-0342
10.1089/10430349950017536 doi
Amyotrophic Lateral Sclerosis--therapy
Animals
Cell Transplantation
Disease Models, Animal
Disease Progression
Genetic Therapy
Genetic Vectors
Glial Cell Line-Derived Neurotrophic Factor
Humans
Mice
Motor Neurons--physiology
Muscle, Skeletal--cytology
Nerve Growth Factors
Nerve Tissue Proteins--genetics
Retroviridae--genetics
Transduction, Genetic
beta-Galactosidase--genetics