Lanosterol analogs: dual-action inhibitors of cholesterol biosynthesis. [electronic resource]
Producer: 19990723Description: 123-40 p. digitalISSN:- 1040-9238
- Animals
- Anticholesteremic Agents -- pharmacology
- CHO Cells
- Coronary Disease -- metabolism
- Cricetinae
- Cytochrome P-450 Enzyme System -- physiology
- Dose-Response Relationship, Drug
- Hydroxymethylglutaryl CoA Reductases -- physiology
- Inhibitory Concentration 50
- Ketones -- chemistry
- Lanosterol -- analogs & derivatives
- Microsomes, Liver -- drug effects
- Models, Biological
- Models, Chemical
- Oxidoreductases -- physiology
- Oximes -- chemistry
- RNA Processing, Post-Transcriptional
- Rats
- Receptors, LDL -- genetics
- Sterol 14-Demethylase
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
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