Lanosterol analogs: dual-action inhibitors of cholesterol biosynthesis.

Frye, L L

Lanosterol analogs: dual-action inhibitors of cholesterol biosynthesis. [electronic resource] - Critical reviews in biochemistry and molecular biology 1999 - 123-40 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

1040-9238

10.1080/10409239991209246 doi


Animals
Anticholesteremic Agents--pharmacology
CHO Cells
Coronary Disease--metabolism
Cricetinae
Cytochrome P-450 Enzyme System--physiology
Dose-Response Relationship, Drug
Hydroxymethylglutaryl CoA Reductases--physiology
Inhibitory Concentration 50
Ketones--chemistry
Lanosterol--analogs & derivatives
Microsomes, Liver--drug effects
Models, Biological
Models, Chemical
Oxidoreductases--physiology
Oximes--chemistry
RNA Processing, Post-Transcriptional
Rats
Receptors, LDL--genetics
Sterol 14-Demethylase
Time Factors