Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. [electronic resource]
Producer: 19990415Description: 3285-92 p. digitalISSN:- 0006-2960
- Arachidonic Acid -- metabolism
- Aryl Hydrocarbon Hydroxylases
- Binding Sites -- genetics
- Blotting, Western
- Catalysis
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- chemistry
- Diclofenac -- metabolism
- Kinetics
- Lauric Acids -- metabolism
- Leucine -- genetics
- Mutagenesis, Site-Directed
- Phenylalanine -- genetics
- Protein Structure, Secondary
- Static Electricity
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- antagonists & inhibitors
- Substrate Specificity -- drug effects
- Sulfaphenazole -- pharmacology
- Warfarin -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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