Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.

Haining, R L

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. [electronic resource] - Biochemistry Mar 1999 - 3285-92 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0006-2960

10.1021/bi982161+ doi


Arachidonic Acid--metabolism
Aryl Hydrocarbon Hydroxylases
Binding Sites--genetics
Blotting, Western
Catalysis
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--chemistry
Diclofenac--metabolism
Kinetics
Lauric Acids--metabolism
Leucine--genetics
Mutagenesis, Site-Directed
Phenylalanine--genetics
Protein Structure, Secondary
Static Electricity
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases--antagonists & inhibitors
Substrate Specificity--drug effects
Sulfaphenazole--pharmacology
Warfarin--metabolism