Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase. [electronic resource]
Producer: 19990413Description: 859-67 p. digitalISSN:- 0022-2623
- Animals
- Anti-HIV Agents -- chemical synthesis
- Antineoplastic Agents -- chemical synthesis
- Drug Screening Assays, Antitumor
- HIV Reverse Transcriptase -- antagonists & inhibitors
- Humans
- Organophosphates -- chemical synthesis
- Rats
- Reverse Transcriptase Inhibitors -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
- Tumor Cells, Cultured
- Zalcitabine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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