Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Shi, J
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase. [electronic resource] - Journal of medicinal chemistry Mar 1999 - 859-67 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0022-2623
10.1021/jm980510s doi
Animals
Anti-HIV Agents--chemical synthesis
Antineoplastic Agents--chemical synthesis
Drug Screening Assays, Antitumor
HIV Reverse Transcriptase--antagonists & inhibitors
Humans
Organophosphates--chemical synthesis
Rats
Reverse Transcriptase Inhibitors--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Tumor Cells, Cultured
Zalcitabine--analogs & derivatives
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase. [electronic resource] - Journal of medicinal chemistry Mar 1999 - 859-67 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0022-2623
10.1021/jm980510s doi
Animals
Anti-HIV Agents--chemical synthesis
Antineoplastic Agents--chemical synthesis
Drug Screening Assays, Antitumor
HIV Reverse Transcriptase--antagonists & inhibitors
Humans
Organophosphates--chemical synthesis
Rats
Reverse Transcriptase Inhibitors--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Tumor Cells, Cultured
Zalcitabine--analogs & derivatives