DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. (Record no. 30029609)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01861 a2200517 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250518054811.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 202011s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1532-6535 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1002/cpt.1615 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Grievink, Hendrika W |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20201112 |
| 245 00 - TITLE STATEMENT | |
| Title | DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Clinical pharmacology and therapeutics |
| Date of publication, distribution, etc. | 02 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 406-414 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Adolescent |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Adult |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Area Under Curve |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Double-Blind Method |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Female |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Half-Life |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Leukocytes, Mononuclear |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Metabolic Clearance Rate |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Middle Aged |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phosphorylation |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptor-Interacting Protein Serine-Threonine Kinases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Young Adult |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heuberger, Jules A A C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huang, Fen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chaudhary, Rinkal |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Birkhoff, Willem A J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tonn, George R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mosesova, Sofia |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Erickson, Rebecca |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moerland, Matthijs |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Haddick, Patrick C G |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Scearce-Levie, Kimberly |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ho, Carole |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Groeneveld, Geert Jan |
| 773 0# - HOST ITEM ENTRY | |
| Title | Clinical pharmacology and therapeutics |
| Related parts | vol. 107 |
| -- | no. 2 |
| -- | p. 406-414 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1002/cpt.1615">https://doi.org/10.1002/cpt.1615</a> |
| Public note | Available from publisher's website |
No items available.