DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Grievink, Hendrika W
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. [electronic resource] - Clinical pharmacology and therapeutics 02 2020 - 406-414 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1532-6535
10.1002/cpt.1615 doi
Adolescent
Adult
Area Under Curve
Dose-Response Relationship, Drug
Double-Blind Method
Female
Half-Life
Humans
Leukocytes, Mononuclear--drug effects
Male
Metabolic Clearance Rate
Middle Aged
Phosphorylation--drug effects
Receptor-Interacting Protein Serine-Threonine Kinases--antagonists & inhibitors
Young Adult
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. [electronic resource] - Clinical pharmacology and therapeutics 02 2020 - 406-414 p. digital
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1532-6535
10.1002/cpt.1615 doi
Adolescent
Adult
Area Under Curve
Dose-Response Relationship, Drug
Double-Blind Method
Female
Half-Life
Humans
Leukocytes, Mononuclear--drug effects
Male
Metabolic Clearance Rate
Middle Aged
Phosphorylation--drug effects
Receptor-Interacting Protein Serine-Threonine Kinases--antagonists & inhibitors
Young Adult