Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. (Record no. 27474504)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02729 a2200817 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517170838.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201710s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/acs.jmedchem.7b00604 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Stepan, Antonia F |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20171016 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | 09 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 7764-7780 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Allosteric Regulation |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Female |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HEK293 Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Heterocyclic Compounds, 3-Ring |
| General subdivision | adverse effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Docking Simulation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridines |
| General subdivision | adverse effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats, Sprague-Dawley |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptor, Metabotropic Glutamate 5 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Claffey, Michelle M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reese, Matthew R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Balan, Gayatri |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Barreiro, Gabriela |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Barricklow, Jason |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bohanon, Michael J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Boscoe, Brian P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cappon, Gregg D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chenard, Lois K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cianfrogna, Julie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Laigao |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Coffman, Karen J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Drozda, Susan E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dunetz, Joshua R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghosh, Somraj |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hou, Xinjun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Houle, Christopher |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Karki, Kapil |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lazzaro, John T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mancuso, Jessica Y |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marcek, John M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miller, Emily L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moen, Mark A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | O'Neil, Steven |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sakurada, Isao |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Skaddan, Marc |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Parikh, Vinod |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Smith, Deborah L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Trapa, Patrick |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tuttle, Jamison B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Verhoest, Patrick R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walker, Daniel P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Won, Annie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wright, Ann S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Whritenour, Jessica |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zasadny, Kenneth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zaleska, Margaret M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Lei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shaffer, Christopher L |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 60 |
| -- | no. 18 |
| -- | p. 7764-7780 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/acs.jmedchem.7b00604">https://doi.org/10.1021/acs.jmedchem.7b00604</a> |
| Public note | Available from publisher's website |
No items available.