Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.

Stepan, Antonia F

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. [electronic resource] - Journal of medicinal chemistry 09 2017 - 7764-7780 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/acs.jmedchem.7b00604 doi


Allosteric Regulation--drug effects
Animals
Female
HEK293 Cells
Heterocyclic Compounds, 3-Ring--adverse effects
Humans
Male
Molecular Docking Simulation
Pyridines--adverse effects
Rats
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5--antagonists & inhibitors
Structure-Activity Relationship