Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects. (Record no. 26103042)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02212 a2200661 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517101028.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201705s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/acs.jmedchem.6b00544 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Davoren, Jennifer E |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20170529 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | 07 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 6313-28 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Female |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Picolinic Acids |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptor, Muscarinic M1 |
| General subdivision | agonists |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Thiazoles |
| General subdivision | chemical synthesis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lee, Che-Wah |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Garnsey, Michelle |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brodney, Michael A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cordes, Jason |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dlugolenski, Keith |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Edgerton, Jeremy R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Harris, Anthony R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Helal, Christopher J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jenkinson, Stephen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kauffman, Gregory W |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kenakin, Terrence P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lazzaro, John T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lotarski, Susan M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mao, Yuxia |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nason, Deane M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Northcott, Carrie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nottebaum, Lisa |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | O'Neil, Steven V |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pettersen, Betty |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Popiolek, Michael |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reinhart, Veronica |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salomon-Ferrer, Romelia |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Steyn, Stefanus J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Webb, Damien |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Lei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Grimwood, Sarah |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 59 |
| -- | no. 13 |
| -- | p. 6313-28 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/acs.jmedchem.6b00544">https://doi.org/10.1021/acs.jmedchem.6b00544</a> |
| Public note | Available from publisher's website |
No items available.