Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.

Davoren, Jennifer E

Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects. [electronic resource] - Journal of medicinal chemistry 07 2016 - 6313-28 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.6b00544 doi


Animals
Dose-Response Relationship, Drug
Drug Discovery
Female
Male
Mice
Models, Molecular
Molecular Structure
Picolinic Acids--chemical synthesis
Rats
Receptor, Muscarinic M1--agonists
Structure-Activity Relationship
Thiazoles--chemical synthesis