Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. (Record no. 22737007)
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| fixed length control field | 03241 a2201033 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250516150656.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201308s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm4004895 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Zak, Mark |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20130820 |
| 245 00 - TITLE STATEMENT | |
| Title | Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jun 2013 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 4764-85 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Administration, Oral |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antirheumatic Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Arthritis, Experimental |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biological Availability |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Membrane Permeability |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Collagen |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dogs |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Haplorhini |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Heterocyclic Compounds, 3-Ring |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Imidazoles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Isoenzymes |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Janus Kinase 1 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Janus Kinase 2 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Madin Darby Canine Kidney Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Microsomes, Liver |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrroles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hurley, Christopher A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ward, Stuart I |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bergeron, Philippe |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Barrett, Kathy |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Balazs, Mercedesz |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Blair, Wade S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bull, Richard |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chakravarty, Paroma |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chang, Christine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Crackett, Peter |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Deshmukh, Gauri |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | DeVoss, Jason |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dragovich, Peter S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eigenbrot, Charles |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ellwood, Charles |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gaines, Simon |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghilardi, Nico |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gibbons, Paul |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gradl, Stefan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gribling, Peter |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamman, Chris |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Harstad, Eric |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hewitt, Peter |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, Adam |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, Tony |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kenny, Jane R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Koehler, Michael F T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bir Kohli, Pawan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Labadie, Sharada |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lee, Wyne P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liao, Jiangpeng |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Liimatta, Marya |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mendonca, Rohan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Narukulla, Raman |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pulk, Rebecca |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reeve, Austin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Savage, Scott |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shia, Steven |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Steffek, Micah |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ubhayakar, Savita |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | van Abbema, Anne |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aliagas, Ignacio |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Avitabile-Woo, Barbara |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xiao, Yisong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, Jing |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kulagowski, Janusz J |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 56 |
| -- | no. 11 |
| -- | p. 4764-85 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm4004895">https://doi.org/10.1021/jm4004895</a> |
| Public note | Available from publisher's website |
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