Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
Zak, Mark
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. [electronic resource] - Journal of medicinal chemistry Jun 2013 - 4764-85 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm4004895 doi
Administration, Oral
Animals
Antirheumatic Agents--chemical synthesis
Arthritis, Experimental--drug therapy
Biological Availability
Cell Membrane Permeability
Collagen
Crystallography, X-Ray
Dogs
Haplorhini
Heterocyclic Compounds, 3-Ring--chemical synthesis
Humans
Imidazoles--chemical synthesis
Isoenzymes--antagonists & inhibitors
Janus Kinase 1--antagonists & inhibitors
Janus Kinase 2--antagonists & inhibitors
Madin Darby Canine Kidney Cells
Microsomes, Liver--metabolism
Models, Molecular
Molecular Structure
Pyridines--chemical synthesis
Pyrroles--chemical synthesis
Rats
Stereoisomerism
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. [electronic resource] - Journal of medicinal chemistry Jun 2013 - 4764-85 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm4004895 doi
Administration, Oral
Animals
Antirheumatic Agents--chemical synthesis
Arthritis, Experimental--drug therapy
Biological Availability
Cell Membrane Permeability
Collagen
Crystallography, X-Ray
Dogs
Haplorhini
Heterocyclic Compounds, 3-Ring--chemical synthesis
Humans
Imidazoles--chemical synthesis
Isoenzymes--antagonists & inhibitors
Janus Kinase 1--antagonists & inhibitors
Janus Kinase 2--antagonists & inhibitors
Madin Darby Canine Kidney Cells
Microsomes, Liver--metabolism
Models, Molecular
Molecular Structure
Pyridines--chemical synthesis
Pyrroles--chemical synthesis
Rats
Stereoisomerism