Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.

Zak, Mark

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. [electronic resource] - Journal of medicinal chemistry Jun 2013 - 4764-85 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm4004895 doi


Administration, Oral
Animals
Antirheumatic Agents--chemical synthesis
Arthritis, Experimental--drug therapy
Biological Availability
Cell Membrane Permeability
Collagen
Crystallography, X-Ray
Dogs
Haplorhini
Heterocyclic Compounds, 3-Ring--chemical synthesis
Humans
Imidazoles--chemical synthesis
Isoenzymes--antagonists & inhibitors
Janus Kinase 1--antagonists & inhibitors
Janus Kinase 2--antagonists & inhibitors
Madin Darby Canine Kidney Cells
Microsomes, Liver--metabolism
Models, Molecular
Molecular Structure
Pyridines--chemical synthesis
Pyrroles--chemical synthesis
Rats
Stereoisomerism