2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept. (Record no. 22220409)

MARC details
000 -LEADER
fixed length control field 01856 a2200505 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250516120158.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201302s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1520-4804
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/jm3010477
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Wilhelm, Adriana
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20130205
245 00 - TITLE STATEMENT
Title 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Journal of medicinal chemistry
Date of publication, distribution, etc. Nov 2012
300 ## - PHYSICAL DESCRIPTION
Extent 9817-30 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article; Research Support, Non-U.S. Gov't
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Allosteric Site
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Binding Sites
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element DNA Helicases
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Drug Design
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Enzyme Activation
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Immunoblotting
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Malonates
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Models, Molecular
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Molecular Structure
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Muscle Cells
General subdivision drug effects
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Prodrugs
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Binding
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Kinase Inhibitors
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Serine-Threonine Kinases
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Pyruvate Dehydrogenase Acetyl-Transferring Kinase
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Structure-Activity Relationship
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lopez-Garcia, Laura A
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Busschots, Katrien
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Fröhner, Wolfgang
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Maurer, Frauke
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Boettcher, Stefan
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, Hua
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Schulze, Jörg O
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Biondi, Ricardo M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Engel, Matthias
773 0# - HOST ITEM ENTRY
Title Journal of medicinal chemistry
Related parts vol. 55
-- no. 22
-- p. 9817-30
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/jm3010477">https://doi.org/10.1021/jm3010477</a>
Public note Available from publisher's website

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