2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.
Wilhelm, Adriana
2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept. [electronic resource] - Journal of medicinal chemistry Nov 2012 - 9817-30 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm3010477 doi
Allosteric Site
Binding Sites
DNA Helicases--antagonists & inhibitors
Drug Design
Enzyme Activation
Humans
Immunoblotting
Malonates--chemical synthesis
Models, Molecular
Molecular Structure
Muscle Cells--drug effects
Prodrugs--chemical synthesis
Protein Binding
Protein Kinase Inhibitors--chemical synthesis
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Structure-Activity Relationship
2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept. [electronic resource] - Journal of medicinal chemistry Nov 2012 - 9817-30 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm3010477 doi
Allosteric Site
Binding Sites
DNA Helicases--antagonists & inhibitors
Drug Design
Enzyme Activation
Humans
Immunoblotting
Malonates--chemical synthesis
Models, Molecular
Molecular Structure
Muscle Cells--drug effects
Prodrugs--chemical synthesis
Protein Binding
Protein Kinase Inhibitors--chemical synthesis
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Structure-Activity Relationship