Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. (Record no. 21906595)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02734 a2200793 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250516101013.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201211s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm300411k |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kosugi, Tomomi |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20121105 |
| 245 00 - TITLE STATEMENT | |
| Title | Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Aug 2012 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 6700-15 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Anti-Inflammatory Agents, Non-Steroidal |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HSP27 Heat-Shock Proteins |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Intracellular Signaling Peptides and Proteins |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Lipopolysaccharides |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Inbred C57BL |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Phosphorylation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Conformation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Serine-Threonine Kinases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrazoles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrimidines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Shock, Septic |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Small Molecule Libraries |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tumor Necrosis Factor-alpha |
| General subdivision | biosynthesis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mitchell, Dale R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fujino, Aiko |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Imai, Minoru |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kambe, Mika |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kobayashi, Shinji |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Makino, Hiroaki |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Matsueda, Yohei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oue, Yasuhiro |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Komatsu, Kanji |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Imaizumi, Keiichiro |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sakai, Yuri |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sugiura, Satoshi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Takenouchi, Osami |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Unoki, Gen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yamakoshi, Yuko |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cunliffe, Vicky |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Frearson, Julie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gordon, Richard |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Harris, C John |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kalloo-Hosein, Heidi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Le, Joelle |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Patel, Gita |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Simpson, Donald J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherborne, Brad |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thomas, Peter S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Suzuki, Naotaka |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Takimoto-Kamimura, Midori |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kataoka, Ken-ichiro |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 55 |
| -- | no. 15 |
| -- | p. 6700-15 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm300411k">https://doi.org/10.1021/jm300411k</a> |
| Public note | Available from publisher's website |
No items available.